There is quite a bit of literature on this subject. One approach is to admit that the Aristotelian categories adopted by the Church to describe transubstantiation do seem to contradict Newtonian physics, but Quantum physics has rendered the debate moot. Father Michael Kelly, the Jesuit CEO of the Asian Catholic news agency UCA News writes:
Regrettably, all too frequently, the only Presence focused on is
Christ’s presence in the elements of bread and wine. Inadequately
described as the change of the ‘substance’ (not the ‘accidents’) of
bread and wine into the body and blood of Christ, the mystery of the
real presence of Christ in the Eucharist carries the intellectual
baggage of a physics no one accepts. Aristotelian physics makes such
nice, however implausible and now unintelligible, distinctions. They
are meaningless in the post-Newtonian world of quantum physics, which
is the scientific context we live in today.
Deacon Steven D. Greydanus goes a step further:
A tesseract or wormhole warps space-time to bridge the distance
between two locations that are far apart within four-dimensional
space. The Eucharist does something similar, except that instead of
two spatial locations, it bridges the infinite distance between Earth
and Heaven; what it makes present is not the other side of the galaxy,
but Christ in Heaven
However, Deacon Greydanus also warns:
Science reveals a world that exceeds the bounds of human experience,
comprehension, and imagination. We cannot form an accurate imaginative
picture of the world of quantum mechanics, any more than we can form
an accurate imaginative picture of the body and blood of Christ being
present under the appearances of bread and wine. Yet quantum theory
allows us to make true statements about the unimaginable world of
quantum physics and to avoid certain false ideas — and theology does
something similar in regard to mysteries of faith.
In the end, for those who believe in the Real Presence, it is not a question of one contradicting each other. It has always been been a Mystery of Faith. On the other hand, who knows if the day is coming when Quantum physics well enable the faithful to "know," as well as to "believe."