Identifying Saints in Icon?
I believe the two saints in the above icon are the the Christian martyrs Saints Cosmas and Damian
Saints Cosmas and Damian (died c. AD 287) were two Arab physicians in the town Cyrrhus, and were reputedly twin brothers, and early Christian martyrs. They practised their profession in the seaport of Aegeae, then in the Roman province of Syria.
As early as the 4th century, churches dedicated to the twin saints were established at Jerusalem, in Egypt and in Mesopotamia. Devotion to the two saints spread rapidly in both East and West. Theodoret records the division of their reputed relics.
Saints Cosmas Damian Antique Greek Orthodox Print Icon on Wood
The two saints are definitely the twin brothers Cosmas and Damian.
It seems probable that the icon indeed dates from the 18th century, but it would have to be properly evaluated by experts, such as historians found at a major and well known museums.