One way to think about this is:
Within the "all that there is" of the universe cause and effect is supremely evident and unavoidably universal. If it were not so we would have no way to predictably interact with our environment. It makes no sense to exempt "all that there is" from the influence of cause and effect.
In other words, if cause and effect reigns supreme within "all that there is" while the totality of "all that there is" itself is uncaused we are left asking, "What has caused "cause and effect"?
If "cause and effect" are byproducts of existence then "all that there is" has no cause and is, itself, the uncaused cause. This leads to pantheism and all manner of paganism and nature worship (including humanism and atheism):
For although they knew God, they did not honor him as God or give thanks to him, but they became futile in their thinking, and their foolish hearts were darkened. Claiming to be wise, they became fools, and exchanged the glory of the immortal God for images resembling mortal man and birds and animals and creeping things. - Romans 1:21-23
If "all that there is" is an effect then what has caused it? And even beyond that, what has caused the cause? Some have supposed an eternal regression of causes with no need for a first, uncaused cause. This seems to require an "all that there is" that is less than inclusive for the cause cannot be part of it's effect.
In other words, if "all that there is" had a cause, that cause must be something other than "all that there is" and if that cause is actually an effect which had a cause (as eternal regressionists propose) we now must suppose something other than cause and effect which caused the cause of "all that there is". Since we cannot possibly even imagine what that would be it is useless to imagine beyond it. Eternal regressionism is foolishness:
... they became futile in their thinking, and their foolish hearts were darkened. Claiming to be wise, they became fools...
What the Scripture declares is "In the beginning God..." and "The heavens are recounting the honour of God, And the work of His hands The expanse is declaring." No effort is made to prove to mankind (merely a part of "all that there is") that God exists: The effect itself is proof of the cause.
That God (first cause) exists is self evident in "all that there is":
For what can be known about God is plain to them, because God has shown it to them.
For his invisible attributes, namely, his eternal power and divine nature, have been clearly perceived, ever since the creation of the world, in the things that have been made. So they are without excuse. - Romans 1:19-20
Who or what God is (God and Father of the Lord Jesus Christ) is the subject of the revelation beyond that which "is plain to them".
He who comes from above is above all. He who is of the earth belongs to the earth and speaks in an earthly way. He who comes from heaven is above all. He bears witness to what he has seen and heard, yet no one receives his testimony. Whoever receives his testimony sets his seal to this, that God is true. - John 3:31-33