The some insulting allusion to JC’s physical appearance by a pre 220AD critic of Christianity Celsum in Origens ‘Contra Celsum’ along with a response from Origen with a cross reference by Origen himself to the Isaiah prophecy;
To the preceding remarks he adds the following: [ie Celsus says]
*"Since a divine Spirit inhabited the body (of Jesus), it must certainly have been different From that of other beings, in respect of grandeur, or beauty, or strength, or voice, or impressiveness, or persuasiveness. For it is impossible that He, to whom was imparted some divine quality beyond other beings, should not differ from others; whereas this person did not differ in any respect from another, but was, as they report, little, and ill-favoured, and ignoble."
Now it is evident by these words, that when Celsus wishes to bring a charge against Jesus, he adduces the sacred writings, as one who believed them to be writings apparently fitted to afford a handle for a charge against Him; but wherever, in the same writings, statements would appear to be made opposed to those charges which are adduced, he pretends not even to know them! There are, indeed, admitted to be recorded some statements respecting the body of Jesus having been "ill-favoured;" not, however, "ignoble," as has been stated, nor is there any certain evidence that he was "little." The language of Isaiah runs as follows………
ie that he may have been physically deformed himself in some way.
They may be a reference to that in the gospel material itself
King James Version (KJV)
23 And he said unto them, Ye will surely say unto me this proverb, Physician, heal thyself: