How has God destroyed the wisdom of the wise?
This "destruction" is pretty much only discernible to those who are "of the truth".
John 18:37 Pilate therefore said unto him, Art thou a king then?
Jesus answered, Thou sayest that I am a king. To this end was I born,
and for this cause came I into the world, that I should bear witness
unto the truth. Every one that is of the truth heareth my voice.
When man was able to receive the indwelling Holy Spirit, he was able to see through many of the lies and deceptions Satan has foisted upon the world;
1 Corinthians 2:14 But the natural man receiveth not the things of
the Spirit of God: for they are foolishness unto him: neither can he
know them, because they are spiritually discerned.
1 Corinthians 1:18 For the preaching of the cross is to them that
perish foolishness; but unto us which are saved it is the power of
The so-called "science" of this age has been diverted to serve as a sort of substitute "truth". It is used to bully people into submission by the power of arrogance and self-appointed authority.
A Christian may be told the an unborn child is only a lump of tissue that can be discarded at will, but knows via the Spirit of truth that this is not true and killing children is wrong.
A Christian may be told that smart people have decided that evolution is true and the there is no God, but have the living God inside of him telling him that rumors of his death have been greatly exaggerated.
A Christian may be told that having the government run everything is the ideal form of society, but think that 16 trillion dollars of debt may not be the most secure foundation on which to build and collectivism only seems to bring slavery.
Satan rules this world (for now and insofar as he is allowed by God).
Ephesians 2:2 Wherein in time past ye walked according to the course
of this world, according to the prince of the power of the air, the
spirit that now worketh in the children of disobedience:
2 Corinthians 2:11 that we may not be over-reached by the Adversary,
for of his devices we are not ignorant.
The "wisdom" of the wise has been destroyed by the penetrating light brought by the Spirit of truth.
Ephesians 5:8 for ye were once darkness, and now light in the Lord;
as children of light walk ye,